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2026

October
De-Orphanizing Modular Secretion Machinery in the Dark Proteome: A 0.64 Å Structural Match Across Extreme Halophiles Oct 14
Vector Search in the Dark Proteome: Bridging Methanogens and Extreme Halophiles Oct 09
Heatmapping the Dark Proteome: Visualizing Structural Correlations Oct 06
Bypassing VRAM Limits: Domain Chunking Massive Proteins in pg_bio Oct 06
Unearthing Hydrogenase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 06
Unearthing Protease: Exploring the Dark Proteome of Extreme Ecosystems! Oct 06
Unearthing Nuclease: Exploring the Dark Proteome of Extreme Ecosystems! Oct 06
Unearthing Nitrogenase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 05
Unearthing Kinase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 05
Unearthing Hydrogenase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 03
Unearthing Carbonic anhydrase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 03
Unearthing Amidase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 02
Unearthing Cellulase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 01
Unearthing Nitrate reductase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 01
Unearthing Topoisomerase: Exploring the Dark Proteome of Extreme Ecosystems! Oct 01
September
Nature's Fertilizer Factory: Deep-Sea Heat and the Secret of Nitrogen Fixation! Sep 30
Breath of the Boiling Springs: Unveiling an Extremophile's Secret Carbon Capture Engine Sep 30
The Boiling Bubble Breaker: A Catalase Echo in a Hot Spring Archaeon Sep 30
The Salt Lake Scrubber: Finding Methane-Eating Enzymes in a Sea of Pink Sep 30
The Crimson Salt-Lover: Uncovering a Mystery Amidase in the Pink Lakes Sep 30
Analyzing 3D Genomic Architecture and Hi-C Contact Maps with SQL Sep 29
Validating the Dark Proteome: Genomic Synteny and PyMOL Alignment in PostgreSQL Sep 28
Scaling ESM-2 Protein Embeddings: Fast Cosine Similarity in PostgreSQL Sep 28
From Pink Salt Lakes to Boiling Acid: Hunting the Ultimate Plastic-Eating Machine Sep 28
The Archaeal Hard Drive: Uncovering a Flawless Cas1 Memory Engine in Methanosarcina mazei Sep 28
The Molecular Shredders of the Deep: Unearthing Halophilic Proteases Sep 28
Bone-Crushers of the Salt Lakes: A Halophilic Secret to Breaking Down Collagen Sep 28
The Asgardian Carbon Trap: Deep-Sea Microbes and the Quest for the Ultimate CO2 Engine Sep 28
The Slime Mold and the Salt Lake: A Lysozyme Tale Sep 28
The Six-Sided Donut of Survival: Uncovering a DNA Repair Motor in the Abyss Sep 28
Illuminating the Unknown: How AI Revealed a Hidden Spark in the Soda Lakes Sep 28
The Methane Makers' Secret: A Deep-Sea Factory for Biodegradable Plastic Sep 27
How to Store and Query 3D Protein Structures in PostgreSQL (Moving Beyond PDB Files) Sep 27
Decoding AI Vector Distances: Uncovering Thiamine Binders in the Dark Proteome Sep 27
Mining the Dark Proteome: Legacy Code with Missing Docs Sep 25
Indexing 3D Space like a Video Game: Finding Drug Targets in SQL Sep 25
Writing a Hybrid Database Operator for Biology (<~>) Sep 25
Why Proteins are just High-Dimensional Vectors (And how to query them in SQL) Sep 25
The 27-Hour Index: Database Optimization and Indexing the Dark Proteome Sep 25
Echoes in the Twilight Zone: Uncovering a Telomerase Cousin in a Methane-Breathing Archaeon Sep 25
The Millet Beer Microbe That Might Eat Our Trash Sep 25
Sifting the Protein Cosmos: Uncovering Fanzors in the Folds of the Dark Proteome Sep 24
TeaFlon Synthetic Biology, Part 8: 3D Genomic Architecture and Plasmid Looping Sep 24
Accelerating Claude's CRISPR Discovery: Equipping AI Agents with Native Bio-Databases Sep 24
Introducing pg_bio: The PostgreSQL Bioinformatics Operating System Sep 23
TeaFlon Synthetic Biology, Part 7: The 419 Limit, Local Inference, and pg_bio Sep 23
TeaFlon (Part 6): Upgrading to TriFusion and Quantum Validation Sep 23
TeaFlon (Part 5): Turning Toxic Waste into Solid Rock Sep 11
TeaFlon (Part 4): Flashing the BIOS with Plasmids and Promoters Sep 11
TeaFlon (Part 3): Compiling the Code in a Physics Simulator Sep 10
Learning to Let Go: Leveraging PostgreSQL's Autovacuum for IVM Sep 10
TeaFlon Part 2: The Swarm Architecture and Biomineralization Sep 09
TeaFlon Part 1: Designing a Synthetic Enzyme to Digest Teflon Sep 09
Vibe Coding Postgres Extensions with pgrx May 30
Spiral: An Experiment in Geometry-Aware Storage for PostgreSQL May 24
April
MCP and Fast: Grepping SQL Code Like a Boss Part 2 Apr 17
Where is your mind? Apr 14
No Excuses Apr 09
March
Saving LLM Tokens with Fast: AST Folding & Dependency Free Mar 29
Ethics & Environment in Computing Mar 24
The Math Behind the Yoga SVG Mar 21
The Validation Model Mar 18
Learning to Breathe Mar 16
The Proxy Life Trap Mar 15
Per-Plan Retention with TimescaleDB Dimensions Mar 13
Git Worktrees: What They Actually Are and Why They Beat Stashing Mar 13
My First Time with Claude Worktrees Mar 11
First week at Hubstaff Mar 09

2018

Retrospective 2018 Dec 30